Endocrine Abstracts

Background: There is controversy about the ideal outcome for radio-active iodine (RAI) treatment in thyrotoxicosis and the optimal dose to be given. Various centres use various doses ranging from 185 mBq to 550 mBq.Aim: Our aim was to determine the thyroid status post RAI treatment for thyrotoxicosis and in those who became hypothyroid, to assess the time of onset of hypothyroidism from the date of RAI treatment administration.Meth...

IntroductionHyponatraemia is the most common electrolyte abnormality encountered within the inpatient setting and is associated with increased morbidity, mortality and length of hospital stay. It compromises a spectrum of symptoms, from being asymptomatic to varying degrees of neurological disturbances including gait abnormalities with increased risk of falls, confusion and rarely seizures. This is of particular relevance in the midst of an aging populat...

Purpose of the studyEvaluation of cerebral microcirculation using contrast and non-contrast magnetic resonance perfusion in patients with type 1 diabetes and cognitive dysfunction.Material and methodsThe study complied with generally accepted ethical rules. The study included 45 patients with type 1 diabetes mellitus with cognitive dysfunction and 20 patients without. All patients were continuously monitored ...

Introduction: Most thyroid nodules are benign. Some studies have shown largest nodule size, specially >4 cm, can predict malignancy and reduce fine needle aspiration (FNA) accuracy. Recent studies, however, have shown conflicting results as to whether nodule size may be used to distinguish at risk-lesions. We attempt to determine whether nodule size predicts thyroid malignancy and to examine accuracy of fine needle aspiration (FNA) by size.Material a...

Introduction: Parathyroid carcinoma (PC) occurs in 0.005% of all malignant tumors and in less than 1% in primary hyperparathyroidism (PHPT), but recent reports indicate increasing incidence of PC.Aim: To estimate the prevalence of PC in Russia and to identify its distinctive characteristics relevant as preoperative markers.Material and methods: We conducted a retrospective study based on the online Russian Registry of 3061 patients...

Background: Parathyroid cancer is a rare pathology, approximately 2 cases per 10, 000, 000 people/year. The five-year survival rate for this disease ranges from 20–85%, and the ten-year survival rate is approximately 15–80%. Timely detection and compliance with algorithms for parathyroid gland cancer diagnostics allows surgical treatment and maximum positive prognosis for patient.Clinical case: Patient 18 y.o., was presented with complaints t...

Introduction: Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies in women. In recent years revised diagnostic criteria for PCOS in adolescent females were disseminated. These new criteria notably encompass the specification of irregular menstrual cycles and hyperandrogenism, with the exclusion of polycystic ovarian morphology. In our study, we aimed to verify whether the clinical presentation of adolescent patients meeting the new criteria is associate...

Background: Tumour growth is critically dependent on blood perfusion, its source of oxygen and nutrients. Therefore, tumour vascularization has become an attractive target for the treatment of many cancers types. The study of endocrine-responsive tumours, in particular, needs improved platforms to screen drugs targeting vascularization that have better resolution and that do not compromise on inter-individual variability.Aim: Hence, we’ve set out to...

Case history: A 35-year-old woman with known hypertriglyceridaemia presented with a one day history of abdominal pain, vomiting and fever. She was 14 weeks pregnant having conceived spontaneously following a period of infertility. She had discontinued her lipid-lowering medication and was managed with diet alone. On examination, she was pyrexial, tachycardic (HR=100 bpm), normotensive (BP=111/71 mmHg), oxygen saturation was 96% on air and she had a tender distended abdomen. A ...

Background: To assess whether the improved service provision introduced under the new Paediatric Diabetes Best Practice Tariff, which includes increased contact with the multi-disciplinary team and greater access to psychology support, has impacted positively on the quality of life (QoL) and glycaemic control of young people with diabetes.Method: In 2011, n=55 children and young people with diabetes completed the Generic Paediatric Quality of Li...